A Case Analysis of Antihypertensive Treatment in a Patient Undergoing CRRT with Comorbid Coronary Heart Disease

Abstract

Continuous Renal Replacement Therapy (CRRT) refers to a set of extracorporeal blood purification techniques, encompassing all treatment modalities that continuously and slowly remove fluids and solutes. Conventional CRRT should be administered continuously for over 24 hours, although the treatment duration can be flexibly adjusted in clinical practice based on patient needs. Its mechanism involves removing excess fluid from the body through ultrafiltration, eliminating small and medium molecular solutes via convection, and clearing inflammatory mediators through adsorption. The objectives of CRRT extend beyond merely replacing impaired renal function; in recent years, its application has expanded to the emergency management of common critical illnesses, making it one of the most vital supportive therapies in the treatment of various critical conditions^[1]. However, CRRT may reduce effective drug concentrations in the body, thereby affecting treatment efficacy and patient prognosis. Therefore, investigating the impact of CRRT on drug clearance in critically ill patients holds significant importance for ensuring clinical drug safety, rational drug application, and reducing adverse drug reactions. This article analyzes the appropriateness of the antihypertensive regimen for this patient by exploring the factors influencing drug clearance during CRRT treatment, along with corresponding drug dosage adjustments, in consideration of the patient’s individual characteristics.